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Mutagenesis vol. 12 no. 4 pp. 285-287, 1997
© 1997 UK Environmental Mutagen Society/Oxford University Press

research-article

Induction of micronuclei by smokeless tobacco on buccal mucosa cells of habitual users

Yusuf Özkul1, Hamiyet Donmez1,3, Aydin Erenmemisoglu2, Halil Demirtas1 and Nalan Imamoglu1

1Department Medical Biology and Genetics, Faculty of Medicine, Erciyes University 38039 Kayseri, Turkey 2Department of Pharmacology, Faculty of Medicine, Erciyes University 38039 Kayseri, Turkey

Maras Powder is a kind of smokeless tobacco widely used in lieu of cigarettes in the South-Eastern region of Turkey. In this study, we have evaluated micronuclei in buccal mucosa cells of habitual Maras Powder users. Therefore, we divided our subjects into three groups—smokeless tobacco users, smokers and non-smokers/non-users. The mean percentage of micronucleated (MN) cells was significantly higher in non-smokers/non-users (P < 0.01). The mean percentage of MN cells was 1.86 ± 0.26 in users and 1.99 ± 0.30 in smokers. There was no difference between the mean percentage of MN cells in these two groups. In conclusion, the genotoxic effect of smokeless tobacco should be considered in addition to other known hazards.

3To whom correspondence should be addressed


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