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Mutagenesis vol. 13 no. 6 pp. 557-565, 1998
© 1998 UK Environmental Mutagen Society/Oxford University Press

review-article

Genetic toxicology of abused drugs: a brief review

Jih-Heng Li1,2,3 and Lih-Fang Lin1

1National Narcotics Bureau, Department of Health, Executive Yuan (Cabinet) Taipei 2Institute of Genetics, National Yang-Ming University Taipei, Taiwan, Republic of China

Although numerous studies have been conducted on abused drugs, most focus on the problems of addiction (dependence) and their neurotoxicities. Now accumulated data have demonstrated that the genotoxicity and/or carcinogenicity of abused drugs can also be detrimental to our health. In this review, commonly abused substances, including LSD, opiates (diacetylmorphine, morphine, opium and codeine), cocaine, cannabis, betel quid and khat, are discussed for their potential genotoxicity/carcinogenicity. The available literature in the field, although not as abundant as for neurotoxicity, clearly indicates the capability of abused drugs to induce genotoxicity.

3To whom correspondence should be addressed at: National Narcotics Bureau, Department of Health, Executive Yuan (Cabinet), 6 Lin-Sheng South Road, Taipei, Taiwan, Republic of China. Tel: (02) 2351 7109; Fax: (02) 2341 1635; Email: nbjhligt{at}ms3.hinet.net


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 CarcinogenesisHome page
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