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Mutagenesis vol. 13 no. 6 pp. 619-624, 1998
© 1998 UK Environmental Mutagen Society/Oxford University Press

research-article

Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine

Taraknath Chatterjee1, Amitabha Muhkopadhyay1, Kalim A. Khan2 and Ashok K.Giri1,3

1Indian Institute of Chemical Biology 4 Raja S.C.Mullick Road, Jadavpur, Calcutta-700 032 2Division of Toxicology, Central Drug Research Institute Chattar Manzil Palace, PO Box 173, Lucknow-226 001, India

Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine, were assessed in the Ames mutagenicity assay (in strains TA97a, TA100, TA102 and TA104) and in vivo sister chromatid exchange (SCE) and chromosome aberration (CA) assays in bone marrow cells of mice. These are the most commonly used antimalarial drugs available at present throughout the world. The results of the bacterial mutagenicity assays showed a very weak mutagenic effect of all three drugs in Salmonella strains TA97a and TA100 both with and without S9 mix and in TA104 only with S9 mix. The results of the in vivo SCE and CA assays indicate that these three drugs are genotoxic in bone marrow cells of mice.

3To whom correspodence should be addressed. Tel: +91 33 473 3491; Fax: +91 33 473 5197; Email: iichbio{at}giascl01.vsnl.net.in


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