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Mutagenesis, Vol. 14, No. 2, 217-220, March 1999
© 1999 UK Environmental Mutagen Society/Oxford University Press

Induced expression of CYP2A5 in inflamed trematode-infested mouse liver

R. Montero1,3, G.J. Gentile2, L. Frederick2, J. McMannis2, T. Murphy2, G. Silva, H. Blankespoor2 and J.M. Gentile2

1 Instituto de Investigaciones Biomédicas, UNAM, México City, DF, México and 2 Department of Biology, Hope College, Holland, MI 49423, USA

Trematode infections have long been associated with specific types of cancer. We investigated the ability of the liver fluke Fasciola hepatica to alter host enzymes in a manner that might provide insight into the phenomenon of biologically associated cancers. Our data demonstrate an increased activity of the CYP2A5 isozyme in male mouse liver infected with F.hepatica. Induction of this enzyme was further assessed immunohistochemically. The infection affected CYP2A5 distribution in hepatic tissue. Inflammation and proliferation in liver tissue were observed at the same time that CYP2A5 activity increased. This enzyme is known to participate in the metabolism of several carcinogens which are commnon contaminants in environments of developing countries where parasitic infections may be prevalent.

3 To whom correspondence should be addressed. Tel: +52 5 622 3845; Fax: +52 5 550 0048; Email: dorinda{at}servidor.unam.mx


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