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Mutagenesis, Vol. 15, No. 1, 57-60, January 2000
© 2000 UK Environmental Mutagen Society/Oxford University Press

p53 intron 7 polymorphisms in urinary bladder cancer patients and controls

Petra Berggren2, Kari Hemminki, Gunnar Steineck1 and the Stockholm Bladder Cancer Group,3

Department of Biosciences at NOVUM, Karolinska Institutet, 141 57 Huddinge and 1 Clinical Epidemiology, Department of Oncology–Pathology, Karolinska Hospital, 171 76 Stockholm, Sweden

A C->T polymorphism in intron 7 of the human tumour suppressor gene p53 was studied in 159 urinary bladder cancer patients and 171 non-cancer controls. The polymorphism was found in 15% of both patients and controls, suggesting that it has no relevance in urinary bladder cancer pathogenesis or aetiology. A second polymorphism, a T->G change located 20 bp downstream of the C->T change, was found in all samples with the C->T change. Our findings indicate that the C->T and the T->G changes occur simultaneously and belong to the same allelotype.

2 To whom correspondence should be addressed. Tel: +46 8 608 92 38; Fax: +46 8 608 15 01; Email: petra.berggren{at}cnt.ki.se

3 The Stockholm Bladder Cancer Group consists of Jan Adolfsson, Eric Borgström, Johan Hansson, Ulf Norming, Gunnar Steineck and Hans Wijkström


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