Mutagenesis, Vol. 15, No. 4, 289-302,
July 2000
© 2000 UK Environmental Mutagen Society/Oxford University Press
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Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
Institut für Zellbiologie, Universitätsklinikum Essen, Virchowstraße 173, D-45122 Essen and 1 Institut für Genetik, Universität GH Essen, Universitätsstraße 5, D-45117 Essen, Germany
DNA double-strand breaks (DSB) are considered to be critical primary lesions in the formation of chromosomal aberrations. DSB may be induced by exogenous agents, such as ionizing radiation, but also occur spontaneously during cellular processes at quite significant frequencies. To repair this potentially lethal damage, eukaryotic cells have evolved a variety of repair pathways related to homologous and illegitimate recombination, also called non-homologous DNA end joining, which may induce small scale mutations and chromosomal aberrations. In this paper we review the major cellular sources of spontaneous DSB and the different homologous and illegitimate recombination repair pathways, with particular focus on their potential to induce chromosomal aberrations.
2 To whom correspondence should be addressed. Tel: +49 201 183 3388; Fax: +49 201 183 2866; Email: guenter.obe{at}uni-essen.de
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