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Mutagenesis, Vol. 15, No. 4, 325-328, July 2000
© 2000 UK Environmental Mutagen Society/Oxford University Press

A new approach to evaluate mechanistic relationships among genotoxic phenomena: validation

Herbert S. Rosenkranz1 and Albert R. Cunningham

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA

In order to determine its applicability for the study of genotoxicity, a recently developed method to probe for possible mechanistic relationships among toxicological phenomena was applied to the induction of mutations in Salmonella typhimurium. Since the basis of this phenomenon is understood, this would provide a test of the applicability of the new method to DNA-based mechanisms. The results presented indicate that significant relationships are indeed found among phenomena involving damage to or modification of DNA but not between them and non-genotoxic phenomena. The present results suggest that the newly developed approach could be applied to test mechanistic hypotheses involving genotoxic phenomena.

1 To whom correspondence should be addressed. Tel: +1 412 624 3001; Fax: +1 412 624 3309; Email: rsnkranz{at}pitt.edu


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