Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (27)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Johns, L.E.
Right arrow Articles by Houlston, R.S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johns, L.E.
Right arrow Articles by Houlston, R.S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Mutagenesis, Vol. 15, No. 5, 399-404, September 2000
© 2000 UK Environmental Mutagen Society/Oxford University Press

Glutathione S-transferase µ1 (GSTM1) status and bladder cancer risk: a meta-analysis

L.E. Johns and R.S. Houlston*

Section of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK

Inter-individual differences in bladder cancer susceptibility may be mediated in part through polymorphic variability in the bioactivation and detoxification of procarcinogens. Glutathione S-transferase µ1 (GSTM1) status has been extensively studied as a risk factor in this context. To clarify the impact of GSTM1 deficiency on bladder cancer risk a meta-analysis of 15 case–control studies from the literature has been carried out using a random effects model. The principal outcome measure was the odds ratio for the risk of bladder cancer. Pooling the studies the odds ratio of bladder cancer risk associated with GSTM1 deficiency was 1.53 (95% confidence limits 1.28–1.84). The relationship between GSTM1 status and bladder cancer risk was not confined to a specific population. This meta-analysis supports the hypothesis that GSTM1 deficiency is a determinant of bladder cancer susceptibility. A review of studies does, however, indicate that greater attention should therefore be paid to the design of future studies. The interaction between GSTM1 and other polymorphisms on the risk of bladder cancer and their interaction with environmental risk factors will only be addressed by well-designed studies based on sample sizes commensurate with the detection of small genotypic risks.

* To whom correspondence should be addressed. Tel: +44 0181 722 4175; Fax: +44 0181 643 0549; Email: r.houlston{at}icr.ac.uk


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
J. P. A. Ioannidis
Effect of Formal Statistical Significance on the Credibility of Observational Associations
Am. J. Epidemiol., August 15, 2008; 168(4): 374 - 383.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. Lai, L. Crevier, and L. Thabane
Genetic Polymorphisms of Glutathione S-Transferases and the Risk of Adult Brain Tumors: A Meta-analysis
Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1784 - 1790.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Iida, K. Itoh, Y. Kumagai, R. Oyasu, K. Hattori, K. Kawai, T. Shimazui, H. Akaza, and M. Yamamoto
Nrf2 Is Essential for the Chemopreventive Efficacy of Oltipraz against Urinary Bladder Carcinogenesis
Cancer Res., September 15, 2004; 64(18): 6424 - 6431.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Y. Zhang and G. B. Gordon
A strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling pathway
Mol. Cancer Ther., July 1, 2004; 3(7): 885 - 893.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Sanyal, F. Festa, S. Sakano, Z. Zhang, G. Steineck, U. Norming, H. Wijkstrom, P. Larsson, R. Kumar, and K. Hemminki
Polymorphisms in DNA repair and metabolic genes in bladder cancer
Carcinogenesis, May 1, 2004; 25(5): 729 - 734.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
L. S. Engel, E. Taioli, R. Pfeiffer, M. Garcia-Closas, P. M. Marcus, Q. Lan, P. Boffetta, P. Vineis, H. Autrup, D. A. Bell, et al.
Pooled Analysis and Meta-analysis of Glutathione S-Transferase M1 and Bladder Cancer: A HuGE Review
Am. J. Epidemiol., July 15, 2002; 156(2): 95 - 109.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.