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Mutagenesis, Vol. 16, No. 3, 257-263, May 2001
© 2001 UK Environmental Mutagen Society/Oxford University Press

Inducible protective processes in animal systems: VIII. Enhancement of adaptive response by nicotinamide

K.P. Guruprasad1 and V. Vasudev2,3

1 Department of Zoology, Manasagangotri, University of Mysore, Mysore, 570 006 and 2 Department of Applied Zoology, Jnanasahyadri, Kuvempu University, B.R. Project-577 115

The molecular mechanism of the adaptive response or inducible DNA repair process has not been clearly demonstrated in eukaryotic systems. The involvement of poly(ADP-ribose) polymerase (PARP), a DNA repair enzyme has been reported in the adaptive response (Shadley and Wolff, 1987; Wiencke, 1987). Hence, the present studies were undertaken to understand the role of PARP in ethyl methanesulfonate (EMS)-induced adaptive response in mouse bone marrow cells by employing the inhibitor of this enzyme, nicotinamide. Inter-, pre- and post-treatments of nicotinamide with EMS were made. The results have revealed that there is a reduction in the frequencies of chromosomal aberrations compared with combined or challenge treatment at the different recovery times tested. These results are discussed with reference to the enhancement of the adaptive response by nicotinamide in mouse bone marrow cells.

3 To whom correspondence should be addressed.


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K.P. Guruprasad, V. Vasudev, M.N. Anilkumar, and S.A. Chethan
Inducible protective processes in animal systems. X. Influence of nicotinamide in methyl methanesulfonate-adapted mouse bone marrow cells
Mutagenesis, January 1, 2002; 17(1): 1 - 8.
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