Mutagenesis, Vol. 18, No. 2, 211-216,
March 2003
© 2003 UK Environmental Mutagen Society/Oxford University Press
Infection of rats with Taenia taeniformis metacestodes increases hepatic CYP450, induces the activity of CYP1A1, CYP2B1 and COH isoforms and increases the genotoxicity of the procarcinogens benzo[a]pyrene, cyclophosphamide and aflatoxin B1
Instituto de Investigaciones Biomédicas and 1 Facultad de Medicina, UNAM, Apdo. Postal 70228, CP 04510, México DF, Mexico and 2 Parasitology Department, University of Asahikawa, Asahikawa, Japan
Infection of rat liver by Taenia taeniformis metacestodes produced an increase in total CYP450 content and induced activity of the CYP1A1, CYP2B1 and COH isoforms. Variations in activity and P450 total content were found with increasing time of infection. During increased activity of P450 isoforms, rats were challenged with carcinogens metabolized by the mentioned isozymes and an increased amount of genotoxic damage was found when benzo[a] pyrene, cyclophosphamide and aflatoxin B1 were used. No change was seen in CYP2E1 activity. These results support previous findings regarding an increased susceptibility to genotoxic damage of infected organisms.
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