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Mutagenesis vol. 18 no. 6 pp. 487-490, November 2003
© 2003 UK Environmental Mutagen Society/Oxford University Press

Aneugenic and clastogenic effects of doxorubicin in human lymphocytes

Alok Dhawan, Mahmood A. Kayani1, James M. Parry1, Elizabeth Parry1 and Diana Anderson2,3

Industrial Toxicology Research Centre, PO Box-80, M.G.Marg, Lucknow 226 001, Uttar Pradesh, India, 1Centre for Molecular Genetics and Toxicology, University of Wales, Swansea SA2 8PP, UK and 2Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK

Doxorubicin, a benzanthroquinone anticancer agent, was examined for its effect on micronucleus induction in cultured human lymphocytes. A statistically significant dose-dependent increase in micronucleus frequency (P < 0.001) in binucleated cells was seen and an increase in the kinetochore-positive (P < 0.001) and kinetochore-negative micronuclei (P < 0.001) was observed. An increase was also observed in the number of necrotic cells, but the frequency of apoptotic cells remained almost constant. This confirms that doxorubicin is both clastogenic and aneugenic.

3To whom correspondence should be addressed. Tel: +44 1274 233569; Fax: +44 1274 309742; Email: d.anderson1{at}bradford.ac.uk


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