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Mutagenesis vol. 19 no. 2 pp. 99-104, March 2004
© 2004 UK Environmental Mutagen Society/Oxford University Press

Individual susceptibility to DNA telomerase inhibitors: a study on the chromosome instability induced by 3'-azido-3'-deoxythymidine in lymphocytes of elderly twins

Daniela Caporossi2, Gabriella Argentin, Monica Pittaluga1, Paolo Parisi1, Bruna Tedeschi, Patrizia Vernole and Rosadele Cicchetti

Department of Public Health and Cell Biology, University of Rome ‘Tor Vergata’, via Montpellier 1, I-00133 Rome, Italy and 1Human Biology Centre, University Institute of Movement Science (IUSM), Rome, Italy

The activation of telomerase in phytohemagglutinin-stimulated peripheral lymphocytes is thought to play a role in telomere maintenance and DNA repair. Considering the importance of this enzyme in both cancer and senescence, we studied the effects of the telomerase inhibitor 3'-azido-3'-deoxythymidine on the frequency of chromosomal aberrations and micronuclei induced in peripheral blood lymphocytes (PBL) of elderly monozygotic and dizygotic twins, evaluated with respect to the genotoxic effects induced in unrelated young subjects. Our results show that the cytogenetic damage induced by 3'-azido-3'-deoxythymidine in human PBL was mainly regulated by genetic factors and allowed the identification of hypersensitive subjects. Ageing, which did not modify the individual susceptibility to 3'-azido-3'-deoxythymidine induction of chromosome aberrations and micronuclei, nevertheless determined an overall increase in nuclear damage.

2To whom correspondence should be addressed. Tel: +39 6 72596066; Fax: +39 6 72596053; Email: caporos{at}uniroma2.it

Received on May 15, 2003; revised on November 13, 2003; accepted on December 22, 2003


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