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Mutagenesis vol. 2 no. 5 pp. 367-370, 1987
© 1987 UK Environmental Mutagen Society/Oxford University Press

other

New evidence for the presence of chromosomes in micronuclei of human and Chinese hamster cells

Silvia Viaggi1, Stefania Bonatti1,3 and Angelo Abbondandolo1,2

1Laboratory of Mutagenesis of IST, V.le Benedetto XV, 10, 16132 Genoa 2Laboratory of Genetics, University of Genoa 3Istituto di Mutagenesi e Differenziamento CNR Pisa, Italy

The aim of this work was to demonstrate the presence of intact chromosomes in micronuclei. Such evidence was based on the re-expression of metaphase chromosomes by micronuclei fused with whole cells. Three different experimental approaches were used; they differed only in the criteria used to discriminate between the chromosomes of micronuclear origin and those present in the cell to which micronuclei were fused. These methods involved the expression of: (a) human chromosomes in mouse cells, (b) radioactively labelled human chromosomes in unlabelled human lymphocytes and (c) Chinese hamster chromosomes in Chinese hamster cells with differentially stained chromosomes. With all methods, evidence for the presence of one or a few chromosomes in micronuclei was obtained.


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