Skip Navigation


Mutagenesis Advance Access originally published online on January 24, 2006
Mutagenesis 2006 21(1):77-81; doi:10.1093/mutage/gel001
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/1/77    most recent
gel001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ünyayar, S.
Right arrow Articles by Gözel, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ünyayar, S.
Right arrow Articles by Gözel, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author 2006. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Cadmium-induced genotoxicity, cytotoxicity and lipid peroxidation in Allium sativum and Vicia faba

Serpil Ünyayar, Ayla Çelik*, F.Özlem Çekiç and Aysin Gözel

Department of Biology, Faculty of Science and Art, Mersin University, 33342 Mersin, Turkey

Cadmium (Cd) is one of the most toxic environmental pollutants affecting cytogenetically the various organisms. The cytogenetic damage in root tip cells exposed to cadmium nitrate (CdNO3) solutions at four different concentrations (1, 10, 100 and 200 µM) was evaluated with biological tests based on micronucleus (MN) assay in two plant species, Allium sativum and Vicia faba. Additionally to the cytogenetic analysis, lipid peroxidation analyses were performed in both A.sativum and V.faba roots. Cd enhanced the MN frequency in both A.sativum and V.faba root tip cells, but no dose-dependent. Induction of MN is not depending on CdNO3 concentrations. Besides, high concentrations of Cd decreased the mitotic index and caused the delay in mitosis stages in both plants, mainly in V.faba. On the other hand, lipid peroxidation was significantly enhanced with external Cd in V.faba. The results clearly indicate that high concentrations of cadmium induce the lipid peroxidation resulting in oxidative stress that may contribute to the genotoxicity and cytotoxicity of Cd ions.

* To whom correspondence should be addressed. Tel: +90 324 361 00 01; Fax: +90 324 361 00 47; Email: a.celik{at}mersin.edu.tr


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.