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Mutagenesis Advance Access originally published online on July 26, 2006
Mutagenesis 2006 21(4):261-264; doi:10.1093/mutage/gel030
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© The Author 2006. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Reliability of mutagen sensitivity assay: an inter-laboratory comparison

Esther Erdei*, Sang-Joon Lee, Qingyi Wei1, Li-E. Wang1, Yan-S. Song2, Dana Bovbjerg3 and Marianne Berwick

University of New Mexico, School of Medicine, Department of Internal Medicine and New Mexico Cancer Research and Treatment Center Albuquerque, NM, USA 1 The University of Texas M. D. Anderson Cancer Center Houston, TX, USA 2 Memorial Sloan-Kettering Cancer Center New York, NY, USA 3 Mount Sinai School of Medicine New York, NY, USA

Mutagen sensitivity is regarded as a genetic susceptibility phenotype for various cancers; it is cytogenetically based and probably involves a number of genes from different DNA repair pathways. This assay has been used in a number of laboratories in the field of epidemiology, where it has been investigated and appears to be a useful susceptibility biomarker for epidemiological studies assessing cancer risks at the population level. One concern about phenotypic assays, such as the mutagen sensitivity assay, has been that there could be wide variation in results depending on the timing of the assay (within individual variation), the individual performing the assay (within observer variation) and the laboratory where the assay has been performed (inter-laboratory variation). We conducted an inter-laboratory comparison study between the Memorial Sloan-Kettering Cancer Center and M. D. Anderson, in which we assessed all these concerns. We did not find any significant variation in any of the assays. The correlation was high for all tests. The good concordance rate between laboratories supports the continued use of the mutagen sensitivity assay by different laboratories, and demonstrates its potential to identify at-risk subgroups among normal individuals and cancer patients alike.

*To whom correspondence should be addressed at: University of New Mexico, School of Medicine, Department of Internal Medicine, Division of Epidemiology and Biostatistics, Molecular Epidemiology Laboratory, MSC08 4630, 1 University of New Mexico Cancer Research Facility, Room 103, Albuquerque, NM 87131-0001, USA. Tel: +1 505 272 4431 or +1 505 272 2577; Fax: +1 505 272 2570; Email: EErdei{at}salud.unm.edu


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 Cancer Res.Home page
X. Wu, J. Gu, and M. R. Spitz
Mutagen Sensitivity: A Genetic Predisposition Factor for Cancer
Cancer Res., April 15, 2007; 67(8): 3493 - 3495.
[Abstract] [Full Text] [PDF]


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