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Mutagenesis Advance Access originally published online on April 11, 2008
Mutagenesis 2008 23(4):317-323; doi:10.1093/mutage/gen017
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© The Author 2008. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

In vivo role of Escherichia coli single-strand exonucleases in SOS induction by gamma radiation

Jorge Serment-Guerrero*, Matilde Breña-Valle and J. Javier Espinosa-Aguirre1

Departamento de Biología, Instituto Nacional de Investigaciones Nucleares, Apartado Postal 18-1027, México DF 110801, México 1Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado Postal 70228, México DF 04510, México

Ionizing radiation causes different types of genetic damage, ranging from base modifications to single- and double-stranded DNA breaks, which may be deleterious or even lethal to the cell. There are different repair or tolerance mechanisms to counteract the damage. Among them is the Escherichia coli SOS system: a set of genes that becomes activated upon DNA damage to confer better opportunities for cell survival. However, since this response is triggered by single-stranded DNA regions, most lesions have to be processed or modified prior to SOS activation. Several genes such as recO, recB and recJ that seem to be required to induce the response have already been reported. The results of this work indicate that the four known E.coli single-strand exonucleases take part in processing gamma radiation damage, though RecJ and ExoI proved to be more important than ExoVII or ExoX. In addition, ExoV as well as glycosylases such as Nth and, to a lesser extent, Fpg are also required. A model intended to explain the role of all these genes in damage processing is presented.

* To whom correspondence should be addressed. Tel: +52 55 5329 7230; Fax: +52 55 5329 7387; Email: josg{at}nuclear.inin.mx

Received on December 14, 2007; revised on February 15, 2008; revised on March 12, 2008; accepted on March 14, 2008.


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