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Mutagenesis Advance Access originally published online on February 4, 2009
Mutagenesis 2009 24(3):233-235; doi:10.1093/mutage/gep001
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© The Author 2009. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Radioprotective effects of hesperidin against genotoxicity induced by {gamma}-irradiation in human lymphocytes

Seyed Jalal Hosseinimehr1,2,*, Aziz Mahmoudzadeh3, Amirhossein Ahmadi1, Soheila Mohamadifar3 and Shahram Akhlaghpoor3,4

1Department of Medicinal Chemistry, Faculty of Pharmacy 2Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran 3Laboratory of Cytogenetics, Novin Medical Radiation Institute, Tehran, Iran 4Department of Radiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

The radioprotective effect of hesperidin against genotoxicity induced by {gamma}-irradiation has been investigated in vivo/in vitro in cultured blood lymphocytes from human volunteers. Peripheral blood samples were collected at 0 (10 min before) and at 1, 2 and 3 h after a single oral ingestion of 250 mg hesperidin. At each time point, the whole blood was exposed in vitro to 150 cGy of 60Co {gamma}-irradiation and then the lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis-blocked binucleated cells. For each volunteer, the results showed a significant increase in the incidence of micronuclei after exposure of cells to {gamma}-irradiation as compared to control samples. The lymphocytes in the blood samples collected at 1 h after hesperidin ingestion and exposed in vitro to {gamma}-rays exhibited a significant decrease in the incidence of micronuclei, compared with similarly irradiated lymphocytes from blood samples collected at 0 h. The maximum protection and decrease in frequency of micronuclei (33%) was observed at 1 h after ingestion of hesperidin. These data have important application for the protection of human lymphocytes from the genetic damage and side effects induced by {gamma}-irradiation in patients undergoing radiotherapy.

* To whom correspondence should be addressed. Tel: +98-151-3261244; Fax: +98-151-3261244; Email: sjhosseinim{at}yahoo.com

Received on July 24, 2008; revised on August 31, 2008; accepted on December 10, 2008.


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