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Mutagenesis Advance Access originally published online on September 17, 2009
Mutagenesis 2009 24(6):507-512; doi:10.1093/mutage/gep036
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© The Author 2009. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case–control studies

Dongying Gu{dagger}, Meilin Wang1,2,{dagger}, Miaomiao Wang1, Zhengdong Zhang1,2 and Jinfei Chen*

Department of Oncology, The Affiliated Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, People's Republic of China 1Department of Molecular and Genetic Toxicology 2Department of Epidemiology and Biostatistics, Cancer Center of Nanjing Medical University, Nanjing 210029, People's Republic of China

Published data regarding the association between the apurinic/apyrimidinic endonuclease 1 (APE1) T1349G (Asp148Glu) polymorphism and cancer risk show inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 27 published studies that included 12 432 cancer cases and 17 349 controls. We used odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the strength of the associations. The overall results suggested that the variant genotypes were associated with a moderately increased risk of all cancer types (OR = 1.09, 95% CI = 1.01–1.18 for TG versus TT; OR = 1.08, 95% CI = 1.00–1.18 for GG/TG versus TT). In the stratified analyses, the risk remained for studies of colorectal cancer, European populations and population-based studies. Although some modest bias could not be eliminated, this meta-analysis supported that the APE1 T1349G polymorphism is a low-penetrance risk factor for cancer development.

* To whom correspondence should be addressed. Tel: +86 25 52271251; Fax: +86 25 52271251; Email: jinfeichen{at}sohu.com

{dagger} These authors contributed equally to this work.

Received on July 19, 2009; revised on August 26, 2009; accepted on September 1, 2009.


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