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Mutagenesis vol. 5 no. 5 pp. 421-423, 1990
© 1990 UK Environmental Mutagen Society/Oxford University Press

discussion

The inclusion of an assay for inherited congenital malformations in the assessment of mutagenicity

George R. Douglas

Mutagenesis Section, Environmental Health Directorate, Department of National Health and Welfare Tunney's Pasture, Ottawa, Ontario K1A 0L2, Canada

A number of national guidelines and regulations on the mutagenicity of chemical substances mandate the assessment of inherited genetic effects. While inherited congenital malformations represent a major component of genetically-based adverse human health effects, tests for such effects are not used by regulatory agencies to evaluate inherited genetic effects. This paper is intended to highlight some of the salient characteristics of inherited congenital malformations which promote a rationale for their use in a regulatory context.


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