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Mutagenesis vol. 5 no. 5 pp. 453-459, 1990
© 1990 UK Environmental Mutagen Society/Oxford University Press

research-article

Analysis of nine known or suspected spindle poisons for mitotic chromosome malsegregation using Saccharomyces cerevisiae D61.M

Silvio Albertini

Pharmaceutical Research, Department of Toxicology, F.Hoffman-La Roche Ltd CH-4002 Basel, Switzerland

We tested nine (cadmium chloride, chloral hydrate, colchicine, diazepam, econazole nitrate, hydroquinone, pyrimethamine, thiabendazole, thimerosal) of the 10 known or suspected spindle poisons of the coordinated programme to study aneuploidy induction sponsored by the Commission of the European Communities using Saccharomyces cerevisiae D61.M (mitotic chromosomal malsegregation system). Mitotic malsegregation of chromosome VII was induced by chloral hydrate, thiabendazole and thimerosal. Diazepam, colchicine, cadmium chloride, econazole nitrate, hydroquinone and pyrimethamine revealed no induction of chromosomal malsegregation.


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