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Mutagenesis vol. 5 no. 5 pp. 515-518, 1990
© 1990 UK Environmental Mutagen Society/Oxford University Press

research-article

Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo

J. Ashby, P.A. Lefevre and C.R. ElCombe

ICI Central ToxiCology Laboratory, Alderley Park, Macclesfield Cheshire, UK

The rodent carcinogen C12-clorinated paraffin (C12-CP) has been evaluated for unscheduled DNA synthesis (UDS) activity in the rat liver in vivo. EvidenCe of cell proliferation was also assessed by measuring Cells undergoing semi-conservative DNA activity (S phase). No evidence of UDS was observed at doses up to 2 g/kg at either 2 or 12 h after dosing. Concomitant positive UDS responses were observed for the liver genotoxins N-nitrosodimethylamine, 4-aminobiphenyl, methyl methanesulphonate, 2-acetylaminofluorene, benzidine and 6-dimethylaminophenylazobenzthiazole. A strong positive response was observed in the Cell proliferation assay for the test agent and the positive control agents quinoline and 4-acetylaminofluorene. These observations are discussed within the context of the rodent carcinogenicity reported for the same sample of C12-CPs as studied by the US National Toxicology Program.


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