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Mutagenesis vol. 8 no. 3 pp. 167-174, 1993
© 1993 UK Environmental Mutagen Society/Oxford University Press

review-article

Mutation, cancer and transgenic models: relevance to the toxicology industry

Neil Sullivan1, David Gatehouse2 and David Tweats2,3

1The Institute of Biotechnology, University of Cambridge Tennis Court Road, Cambridge CB2 1QT 2Department of Genetic and Reproductive Toxicology, Glaxo Group Research Ltd Ware, Hertfordshire SG12 0DP, UK

The number and structural diversity of new compounds that are currently being introduced into the environment underlies the need to provide more sensitive toxicology tests. Ideally,these should involve tests that reduce dependence upon animal experimentation; over the past few years a step towards achieving this goal has arisen from the ability to construct transgenic animals. By the inclusion of a suitable marker gene or genetic predisposition to a given disease state several potentially valuable new tests have become available. Here we assess the potential of these systems for use by the toxicologist and consider the future of this technology to the industry.

3To whom correspondence should be addressed


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