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Mutagenesis Advance Access published online on November 5, 2009
Mutagenesis, doi:10.1093/mutage/gep051
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© The Author 2009. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

DNA damage detected by the alkaline comet assay in the liver of mice after oral administration of tetrachloroethylene

Håkan Cederberg*, Jörgen Henriksson and Mona-Lise Binderup1

Swedish Chemicals Agency, PO Box 2, S-172 13 Sundbyberg, Sweden 1Department of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark

Induction of DNA damage in the liver and kidney of male CD1 mice was studied by means of the alkaline Comet assay after oral administration of tetrachloroethylene at the doses of 1000 and 2000 mg/kg/day. A statistically significant dose-related increase in tail intensity was established in hepatocytes, indicating that tetrachloroethylene induced DNA damage in the liver. No effect on DNA damage was observed in the kidney. The results are in agreement with carcinogenicity data in mice, in which tetrachloroethylene induced tumours in the liver but not in the kidney, and support that a genotoxic mode of action might be involved in liver carcinogenicity in mice. An alternative interpretation of the results conveyed by the Study director at the test facility, involving that tetrachloroethylene did not induce DNA damage in the liver and kidney of mice, is also presented and discussed.

* To whom correspondence should be addressed. Tel: +46 8 519 41 299; Fax: +46 8 735 76 98; Email: Hakan.Cederberg{at}kemi.se

Received on April 28, 2009; revised on October 12, 2009; accepted on October 12, 2009.


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