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Mutagenesis, Vol. 17, No. 5, 445-446, September 2002
© 2002 UK Environmental Mutagen Society/Oxford University Press

LETTER TO THE EDITOR

Concerning the CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis

Heather Spencer Feigelson1, Roberta McKean-Cowdin2 and Brian E. Henderson 3

1 Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road, NW Atlanta, GA 30329-4251, US, 2 Department of Preventive Medicine, University of Southern California Keck School of Medicine, USC/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, MS # 44, Los Angeles, CA 90033-0800, US

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Ye and Parry (2002) recently presented a meta-analysis of the CYP17 MspA1 polymorphism and breast cancer. While it is appealing to come up with a summary effect across studies, a meta-analysis is not the best approach to resolve the CYP17–breast cancer association. A meta-analysis for this set of data is of questionable validity, as the studies that have been done . . . [Full Text of this Article]


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