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Mutagenesis, Vol. 17, No. 5, 447-448, September 2002
© 2002 UK Environmental Mutagen Society/Oxford University Press

RESPONSE TO THE LETTER TO THE EDITOR

Concerning the CYP17 MSPA1 polymorphism and breast cancer risk: a meta-analysis

Zheng Ye1, and James M. Parry2

1 Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales, Swansea, Singleton Park, Swansea,SA2 8PP, UK 2 Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales, Swansea, Singleton Park, Swansea,SA2 8PP, UK

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Feigelson and colleagues have raised some important points concerning the selection of the data sets and the application of meta-analysis to resolve some of the problems associated with determining the relationships between metabolic polymorphisms and susceptibility to various disease conditions. In recent years, many meta-analyses have been published with the aim of providing more objective and quantitative summaries of genetic association studies (Lau et al., 1998Go; Dunning et al., 1999Go; de Jong et al., 2001). However, there are always concerns that combining studies with different . . . [Full Text of this Article]


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