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Mutagenesis, Vol. 16, No. 3, 289, May 2001
© 2001 UK Environmental Mutagen Society/Oxford University Press

Book review

Annual Review of Genomics and Human Genetics

Edited by Eric Lander (Editor), David Page and Richard Lipton (Associate Editors) Annual Reviews (2000) 582 Pages Price $165.00 (hardback) ISBN 0-8243-3701-8

Francis L. Martin

The editors see fit to start the 21st century by inaugurating a new Annual Reviews series aimed at distilling insights from genomics and human genetics, two intertwined and important fields. It is a publication that consists of 19 papers. The editors have assembled an impressive list of contributors who examine and review different areas within the genomics and human genetics fields. Papers are well presented and full of relevant detail on historical facts, recent advances, theory and suggestions for future study, and up-to-date references. There is, also, a useful index.

This book traces the lineage from genetics right through to genomics and back again. Genomics takes comprehensive, global views to understand the basis of cellular, developmental and physiological circuitry. To achieve this aim it draws on biology, biochemistry, engineering, mathematics and computer science. In doing so it has removed many of the limitations in the study of human genetics. Through genomics it is rapidly becoming possible to study the entire human population as if it were a single large pedigree, to directly study human tissue samples using global views of the complete DNA, RNA and protein inventory. This book aims to cover these fields in the broadest sense whilst including within their mandate the biological, chemical, technological, computational and social issues related to these fields.

For anyone aiming to understand the genetic contributions to human disease, and how it may impact upon medicine and society, this is a must-have book. It achieves all its aims and brings together these two enormous areas of research in a concise yet readable fashion. I wholeheartedly recommend this book to individuals involved in these areas of research and to the readership of Mutagenesis in general.


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This Article
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