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Mutagenesis, Vol. 18, No. 3, 309, May 2003
© 2003 UK Environmental Mutagen Society/Oxford University Press

RESPONSE TO THE LETTER TO THE EDITOR

Re: Chromosomal aberration, micronucleus and Comet assays on peripheral blood lymphocytes of leprosy patients undergoing multidrug treatment (Mutagenesis, 17, 309–312, 2002)

K. Kalaiselvi, P. Rajaguru, M. Palanivel, M.V. Usharani1, and G. Ramu2,

Department of Environmental Science, PSG College of Arts and Science, Coimbatore 641 014, India, 1 Department of Environmental Science, Bharathiar University, Coimbatore, India and 2 GKNM Hospital Quarters, Coimbatore, India

It was a delight to go through the comments on our paper. We agree with most of the points raised by Dr Nersesyan. For our study the peripheral blood lymphocytes were collected from 34 multibacillary (MB) and 16 paucibacillary (PB) leprosy patients, who were under a multidrug therapy (MDT) regimen (Table 1) recommended by WHO, and subjected to cytogenetic studies and the Comet assay. In our study we did not observe any significant difference in the incidence of genetic damage between the two groups and so we did not segregate the types for the presentation.

Regarding the mechanism, in our paper we have clearly stated that the observed cytogenetic damage in lymphocytes of leprosy patients may be due to any or all of the mechanisms mentioned. As stated in our paper, the following studies are being conducted in our laboratory to clarify the possible role of infection.

  1. The effects of antileprotic drugs, with and without metabolic activation, on lymphocytes collected from normal and leprosy patients (MDT treated and untreated).
  2. Cytogenetic studies in untreated leprosy patients and their DNA repair capacity.


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  		Table I. . Clinical manifestation and the drug schedule of the patients
 
Notes

3 To whom correspondence should be addressed. Tel: +91 422 573386; Fax: +91 422 575622; Email: kalaiselvi{at}rediffmail.com Back

Received on January 27, 2003; accepted on February 3, 2003.


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G. Gandhi and B. Singh
DNA damage studies in untreated and treated leprosy patients
Mutagenesis, November 1, 2004; 19(6): 483 - 488.
[Abstract] [Full Text] [PDF]

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