Mutagenesis, Vol. 14, No. 6, 581-586,
November 1999
© 1999 UK Environmental Mutagen Society/Oxford University Press
Sister chromatid exchanges, chromosome aberrations and micronuclei in female lymphocytes: correlations with biological rhythms, miscarriages and contraceptive pill use
Dipartimento di Scienze dell'Uomo e dell'Ambiente, Università di Pisa, Via S.Giuseppe 22, 56100-Pisa, Italy
Our study looked at the variation in peripheral blood lymphocytes, during the menstrual cycle, of frequencies of sister chromatid exchanges (SCE) and micronuclei (MN) in 819 women and cells with aberrant chromosomes (CA) in a selected sample of 136 volunteers. We observed significant fluctuations in SCE and CA frequencies: SCEs reached a maximum value at the end of menstruation and a low at the time of ovulation, whereas CAs showed a continuous increase from the beginning of the menstrual cycle up to the time of ovulation and a progressive decrease thereafter. MN frequency did not fluctuate in a statistically significant way. No statistically significant differences in SCE, CA and MN frequencies were observed when fertile women were compared with women taking the contraceptive pill or those in menopause and no difference was found between women who had undergone physiological or surgically induced menopause. Moreover, no difference was found between women with a history of miscarriages and matched controls. These data together suggest that the natural variations in sexual hormone levels, but not those due to the contraceptive pill or their reduction at menopause, can contribute in modulating the baseline frequencies of SCEs and CAs. Moreover, these data suggest that the increased risks either of producing a chromosome imbalance in the progeny (eliciting miscarriages) or of occurrence of gynaecological diseases is not predictable by evaluating cytogenetic end-points in peripheral blood lymphocytes.
1 To whom correspondence should be addressed. Tel: +39 50 551217; Fax: +39 50 551290; Email: r.barale{at}geog.unipi.it
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Kopjar, I. Milas, V. Garaj-Vrhovac, and M. Gamulin Cytogenetic outcomes of adjuvant chemotherapy in non-target cells of breast cancer patients Human and Experimental Toxicology, May 1, 2007; 26(5): 391 - 399. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Krol, A. Lankoff, I. Buraczewska, E. Derezinska, and A. Wojcik Radiation-induced micronucleus frequencies in female peripheral blood lymphocytes collected during the first and second half of the menstrual cycle Radiat Prot Dosimetry, March 1, 2007; 123(4): 483 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Al-Qashi, K M Al-Qaoud, M Ja'fer, and A M Khalil Immunocytogenetic effects of gonadotropin releasing hormone analogue: Triptorelin Pamoate (Decapeptyl (R)) during in vitro fertilization treatment Human and Experimental Toxicology, October 1, 2006; 25(10): 593 - 597. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Costa, J. P. Teixeira, S. Silva, J. Roma-Torres, P. Coelho, J. Gaspar, M. Alves, B. Laffon, J. Rueff, and O. Mayan Cytogenetic and molecular biomonitoring of a Portuguese population exposed to pesticides Mutagenesis, September 1, 2006; 21(5): 343 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Gabriel, Z. Liu, J. W. Crott, S.-W. Choi, B. C. Song, J. B. Mason, and E. J. Johnson A Comparison of Carotenoids, Retinoids, and Tocopherols in the Serum and Buccal Mucosa of Chronic Cigarette Smokers versus Nonsmokers. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 993 - 999. [Abstract] [Full Text] [PDF]
|
|