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Mutagenesis, Vol. 15, No. 6, 531-535, November 2000
© 2000 UK Environmental Mutagen Society/Oxford University Press

Variability of G2 checkpoint sensitivity to low doses of X-rays (2 cGy): correlation with G2 chromatid aberrations but not with an adaptive response

V. Pretazzoli, B. Salone, A. Bosi and G. Olivieri1

Department of Genetics and Molecular Biology, University `La Sapienza', P. le A.Moro 5, 00185 Rome, Italy

Using human lymphocytes from a group of 20 donors, we investigated (i) the X-ray-induced adaptive response (AR) after four different conditioning treatments of 1, 2, 4 and 6 cGy, (ii) chromosomal sensitivity to X-irradiation during G2 and (iii) the G2/M checkpoint response. An AR was found in 11 of the 18 donors (~60%). No correlation was found between the presence of AR and G2 chromosomal radiosensitivity, or with donor sensitivity to the activation of the G2/M checkpoint by 30 cGy or a dose as low as 2 cGy. The AR was not related to any particular conditioning treatment, but was consistently present or absent in any one donor under all conditioning treatments used. As far as chromosomal breakage and induced mitotic delay in G2 are concerned, large variability between individuals was observed, together with a close correlation in the same donor between mitotic delay induced by a low dose (2 cGy) and the frequency of aberrations.

1 To whom correspondence should be addressed. E-mail: olivieri{at}axcasp.caspur.it


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