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Mutagenesis, Vol. 16, No. 6, 529-537, November 2001
© 2001 UK Environmental Mutagen Society/Oxford University Press

Chromosome instability induced in the cell progeny of human T lymphocytes irradiated in G0 with {gamma}-rays

E. Bortoletto1,2, M. Mognato1, P. Ferraro1, S. Canova1, R. Cherubini2, L. Celotti1,2 and A. Russo1,4

1 Department of Biology, University of Padova, Via U. Bassi 58/B, 35020 Legnaro, Padova, Italy 2 INFN-LNL, National Laboratories of Legnaro Via Roma 4, 35020 Legnaro, Padova, Italy

We report the occurrence of chromosome instability in human T lymphocytes irradiated in vitro with {gamma}-rays and cultured for several generations before analysis. The delayed effects of {gamma}-radiation have been evaluated by conventional and molecular (chromosome painting) cytogenetics in preparations obtained from long-term bulk cultures or clonal cultures. The results indicate that the cell progeny of {gamma} irradiated human T lymphocytes can be characterized by a higher rate of chromosome damage, but this effect depends on the individual donor response to ionizing radiation. Evidence has been collected about a differential involvement of chromosomes 7, 9 and 19 in the induced chromosome rearrangements, and this effect is equally visible as an immediate or delayed response of human T lymphocytes to ionizing radiation.

4 To whom correspondence should be addressed. Email: antonella.russo{at}uninsubria.it


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