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Mutagenesis, Vol. 17, No. 3, 215-217, May 2002
© 2002 UK Environmental Mutagen Society/Oxford University Press

Induction effects of sulfur dioxide inhalation on chromosomal aberrations in mouse bone marrow cells

Ziqiang Meng,1 and Bo Zhang

Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006, People's Republic of China

To investigate the induction of chromosome aberrations (CA) in mouse bone marrow cells by sulfur dioxide (SO2) inhalation, mice were treated by SO2 exposure for 4 h/day for 7 days at various concentrations of SO2, then mitotic indices and CA in mouse bone marrow cells were analyzed. The present results show that SO2 might increase the frequencies of CA and aberrant cells in mouse bone marrow in a dose-dependent manner. The frequencies (%) of aberrant cells in mouse bone marrow induced by SO2 at concentrations of 0, 7, 14, 28 and 56 mg/m3 were 1.81, 3.00, 3.58, 4.26, 4.86, respectively. At low concentrations SO2 induced only chromatid-type CA, while at high concentrations SO2 induced both chromatid-type and chromosome-type CA. SO2 inhalation decreased the mitotic indices of bone marrow cells. The results imply that SO2 inhalation may inhibit mitoses and increase CA frequencies of bone marrow cells and that it is a clastogenetic and genotoxic agent. Long exposure to SO2 pollution at low concentrations in the environment may be a potential risk for induction of cytogenetic damage in vivo in humans.

1 To whom correspondence should be addressed. Tel: +86 351 7011895; Fax: +86 351 7011895; Email: zqmeng{at}sxu.edu.cn


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Z. Meng, G. Qin, B. Zhang, and J. Bai
DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice
Mutagenesis, November 1, 2004; 19(6): 465 - 468.
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