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Mutagenesis, Vol. 17, No. 3, 257-260, May 2002
© 2002 UK Environmental Mutagen Society/Oxford University Press

Fumonisin B1 is genotoxic in human derived hepatoma (HepG2) cells

Veronika Ehrlich,3, Firouz Darroudi1,3, Maria Uhl, Hans Steinkellner, Markus Zsivkovits and Siegfried Knasmueller,2

Institute of Cancer Research, University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria and 1 Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Centre, 2333 AL Leiden, The Netherlands

Fumonisin B1 (FB1), a widespread Fusarium toxin which is frequently found in corn, causes liver tumors in laboratory rodents and is a suspected human carcinogen. The compound was tested in micronucleus (MN) and single cell gel electrophoresis (SCGE) assays in human derived hepatoma (HepG2) cells and caused a pronounced dose-dependent genotoxic effect at exposure concentrations 25 µg/ml. In contrast, no induction of his+ revertants was found in Salmonella microsome assays with strains TA98, TA100, TA102, TA1535 and TA1537 upon addition of HepG2-derived enzyme (S9) mix in liquid incubation assays with identical exposure concentrations. Taken together, our results indicate that FB1 is clastogenic in human derived cells. This observation supports the assumption that this compound may act as a genotoxic carcinogen in humans.

2 To whom correspondence should be addressed. Tel: +43 01 4277 65142; Fax: +43 01 4277 9651; Email: siegfried.knasmueller{at}univie.ac.at

3 The first two authors contributed equally to this work


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