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Mutagenesis, Vol. 18, No. 1, 53-58, January 2003
© 2003 UK Environmental Mutagen Society/Oxford University Press

Induction of sister chromatid exchanges by cypermethrin and carbosulfan in bone marrow cells of mice in vivo

Sarbani Giri3, Anirudha Giri, Gouri Dutt Sharma2 and Surya Bali Prasad1

Genetic Toxicology Laboratory, Department of Life Science, Assam University, PO Box 11, Silchar 788 011, India and 1 Cell and Tumor Biology Laboratory, Department of Zoology, North-Eastern Hill University, Shillong 793 022, India

The public health effects of pesticides cannot be denied. However, the undesired effects of chemical pesticides have been recognized as a serious public health concern during the past decades. The present study describes the genotoxic effects of two pesticides, namely cypermethrin and carbosulfan, in a murine test system in vivo. The test parameter used was analysis of sister chromatid exchanges (SCE) in bone marrow cells. Both cypermethrin (5, 10 and 20 mg/kg) and carbosulfan (1.25, 2.5 and 5 mg/kg) induced significant increases in the frequency of SCEs (P < 0.001). However, no significant dose–response correlation could be found for either of the pesticides. Carbosulfan induced a cell cycle delay, as evidenced by an increase in average generation time accompanied by accumulation of cells in the first division cycle, but cypermethrin did not induce any such response. The present study indicates that carbosulfan has a higher potential to cause genetic alterations than cypermethrin in mice and may also pose a mutagenic risk to human beings.

2 Present address: Nagaland University, Lumami, Kohima 797 001, India

3 To whom correspondence should be addressed. Tel: 91 3842 40400; Fax: 91 3842 70802; Email: sarbani1{at}sancharnet.in; girisarbani{at}yahoo.com


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