Mutagenesis vol. 19 no. 3 pp. 169-185,
May 2004
© 2004 UK Environmental Mutagen Society/Oxford University Press
Endogenous DNA damage in humans: a review of quantitative data
Study Centre for Carcinogenesis and Primary Prevention of Cancer, Department of Radiotherapy, Nuclear Medicine and Experimental Cancerology, Ghent University, Universitair ziekenhuis 4K3, De Pintelaan 185, B9000 Gent, Belgium
DNA damage plays a major role in mutagenesis, carcinogenesis and ageing. The vast majority of mutations in human tissues are certainly of endogenous origin. A thorough knowledge of the types and prevalence of endogenous DNA damage is thus essential for an understanding of the interactions of endogenous processes with exogenous agents and the influence of damage of endogenous origin on the induction of cancer and other diseases. In particular, this seems important in risk evaluation concerning exogenous agents that also occur endogenously or that, although chemically different from endogenous ones, generate the same DNA adducts. This knowledge may also be crucial to the development of rational chemopreventive strategies. A list of endogenous DNA-damaging agents, processes and DNA adduct levels is presented. For the sake of comparison, DNA adduct levels are expressed in a standardized way, including the number of adducts per 106 nt. This list comprises numerous reactive oxygen species and products generated as a consequence (e.g. lipid peroxides), endogenous reactive chemicals (e.g. aldehydes and S-adenosylmethionine), and chemical DNA instability (e.g. depurination). The respective roles of endogenous versus exogenous DNA damage in carcinogenesis are discussed.
1 To whom correspondence should be addressed. Tel: +32 9 240 66 12; Email: nicolas.vanlarebeke{at}ugent.be
Received on August 1, 2003; revised and accepted on March 11, 2004
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. M. Weems, Ned. S. Cutler, C. Moore, W. K. Nichols, D. Martin, E. Makin, J. G. Lamb, and G. S. Yost 3-Methylindole is Mutagenic and a Possible Pulmonary Carcinogen Toxicol. Sci., November 1, 2009; 112(1): 59 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H.J. Hoeijmakers DNA Damage, Aging, and Cancer N. Engl. J. Med., October 8, 2009; 361(15): 1475 - 1485. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Wang, R. Yan, D. Luo, K. Watabe, D.-F. Liao, and D. Cao Aldo-keto Reductase Family 1 Member B10 Promotes Cell Survival by Regulating Lipid Synthesis and Eliminating Carbonyls J. Biol. Chem., September 25, 2009; 284(39): 26742 - 26748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Shokolenko, N. Venediktova, A. Bochkareva, G. L. Wilson, and M. F. Alexeyev Oxidative stress induces degradation of mitochondrial DNA Nucleic Acids Res., May 1, 2009; 37(8): 2539 - 2548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Sturmey, C. P. Wild, and L. J. Hardie Removal of red light minimizes methylene blue-stimulated DNA damage in oesophageal cells: implications for chromoendoscopy Mutagenesis, May 1, 2009; 24(3): 253 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tubiana, L. E. Feinendegen, C. Yang, and J. M. Kaminski The Linear No-Threshold Relationship Is Inconsistent with Radiation Biologic and Experimental Data Radiology, April 1, 2009; 251(1): 13 - 22. [Full Text] [PDF]
|
|
|
|
|
|
A. Dimitri, J. A. Burns, S. Broyde, and D. A. Scicchitano Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase Nucleic Acids Res., November 1, 2008; 36(20): 6459 - 6471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Chastain II, J. Nakamura, J. Swenberg, and D. Kaufman Nonrandom AP site distribution in highly proliferative cells FASEB J, December 1, 2006; 20(14): 2612 - 2614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. v. Brocke, H. H. Schmeiser, M. Reinbold, and M. Hollstein MEF immortalization to investigate the ins and outs of mutagenesis Carcinogenesis, November 1, 2006; 27(11): 2141 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Amosova, R. Coulter, and J. R. Fresco Self-catalyzed site-specific depurination of guanine residues within gene sequences PNAS, March 21, 2006; 103(12): 4392 - 4397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Singh and P. B. Farmer Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection Carcinogenesis, February 1, 2006; 27(2): 178 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shibata, N. Glynn, T. B. H. McMurry, R. S. McElhinney, G. P. Margison, and D. M. Williams Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT). Nucleic Acids Res., January 1, 2006; 34(6): 1884 - 1891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhou, K. Taghizadeh, and P. C. Dedon Chemical and Biological Evidence for Base Propenals as the Major Source of the Endogenous M1dG Adduct in Cellular DNA J. Biol. Chem., July 8, 2005; 280(27): 25377 - 25382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. L. Neeley, J. C. Delaney, P. T. Henderson, and J. M. Essigmann In Vivo Bypass Efficiencies and Mutational Signatures of the Guanine Oxidation Products 2-Aminoimidazolone and 5-Guanidino-4-nitroimidazole J. Biol. Chem., October 15, 2004; 279(42): 43568 - 43573. [Abstract] [Full Text] [PDF]
|
|