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Mutagenesis Advance Access originally published online on March 8, 2005
Mutagenesis 2005 20(2):101-104; doi:10.1093/mutage/gei013
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© The Author 2005. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please email: journals.permissions@oupjournals.org

In vitro effect of karathane LC (dinocap) on human lymphocytes

Mustafa Çelik1, Fatma Ünal2,*, Deniz Yüzbasioglu2, Mehmet Ali Ergün3, Orhan Arslan4 and Resat Kasap5

1Sütçü Imam Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Kahramanmaras-Turkey, 2Gazi Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Teknikokullar, 06500 Ankara-Turkey, 3Gazi Üniversitesi, Tip Fakültesi, Tibbi Genetik Bölümü, Ankara-Turkey, 4Gazi Üniversitesi, Gazi Egitim Fakültesi, Biyoloji Egitimi Bölümü, 06500 Ankara-Turkey and 5Gazi Üniversitesi, Fen-Edebiyat Fakültesi, Istatistik Bölümü, 06500 Ankara-Turkey

Karathane LC (active ingredient dinocap), a contact fungicide and a non-systemic acaricide was investigated for its ability to induce chromosome aberrations (CAs) and sister chromatid exchanges (SCEs) in cultured human lymphocytes of peripheral blood. In addition to the cytogenetic analysis, the effect of karathane LC on the cell proliferation kinetics (CPK) by the replication index (RI) was studied. The mitotic index (MI) was also determined to detect the cytotoxic effect. Lymphocytes were treated with four different concentrations (5, 10, 15 and 20 µg/ml) of karathane LC for 24 and 48 h. Significant differences between exposed and non-exposed groups found in CAs, SCEs and MI demonstrate the mutagenic, clastogenic and also the cytotoxic effect of karathane LC.

* To whom correspondence should be addressed. Tel: +90 312 212 60 30/3061; Fax: +90 312 212 22 79; Email: funal{at}gazi.edu.tr


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