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Mutagenesis Advance Access originally published online on April 20, 2005
Mutagenesis 2005 20(3):153-163; doi:10.1093/mutage/gei031
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© The Author 2005. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please email: journals.permissions@oupjournals.org

REVIEW

Tails of histones in DNA double-strand break repair

Elizabeth Bilsland and Jessica A. Downs*

Department of Biochemistry, Cambridge University, 80 Tennis Court Road, Cambridge CB2 1GA, UK

DNA double-strand breaks (DSBs) are, arguably, the most deleterious form of DNA damage. An increasing body of evidence points to the inaccurate or inefficient repair of DSBs as a key step in tumorigenesis. Therefore, it is of great importance to understand the processes by which DSBs are detected and repaired. Clearly, these events must take place in the context of chromatin in vivo, and recently, a great deal of progress has been made in understanding the dynamic and active role that histone proteins and chromatin modifying activities play in DNA DSB repair. Here, we briefly review some of the most common techniques in studying DNA DSB responses in vivo, and focus on the contributions of covalent modifications of core histone proteins to these DNA DSB responses.

* To whom correspondence should be addressed. Tel: +01223 333 663; Fax: +01223 766 002; Email: jad32{at}mole.bio.cam.ac.uk


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