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Mutagenesis Advance Access originally published online on June 14, 2006
Mutagenesis 2006 21(4):219-224; doi:10.1093/mutage/gel024
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© The Author 2006. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

TDP1-dependent DNA single-strand break repair and neurodegeneration

Sherif F. El-Khamisy1,2,* and Keith W. Caldecott1

1 Genome Damage and Stability Centre, University of Sussex Falmer, Brighton BN1 9RQ, UK 2 Biochemistry Department, Faculty of Pharmacy, Ain Shams University PO Box 11566, Cairo, Egypt

DNA single-strand breaks (SSBs) are the commonest DNA lesions that arise spontaneously in living cells. Cells employ efficient processes for the rapid repair of these breaks and defects in these processes appear to preferentially impact on the nervous system, causing human ataxia. Spinocerebellar ataxia with axonal neuropathy (SCAN1) is a human disease that is associated with a defect in repairing certain types of SSBs. Although it is a rare neurodegenerative disease, understanding the molecular basis of SCAN1 will lead to better understanding of the mechanisms that underpin not only neurodegeneration but also cancer.

*To whom correspondence should be addressed. Tel: +1273 877511; Fax: +1273 678121; Email: smfame20{at}sussex.ac.uk


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