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Mutagenesis Advance Access originally published online on December 9, 2006
Mutagenesis 2007 22(1):3-4; doi:10.1093/mutage/gel056
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© The Author 2006. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Harmonisation of the micronucleus assay in human buccal cells—a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007

Michael Fenech1,*, Claudia Bolognesi2, Micheline Kirsch-Volders3, Stefano Bonassi4, Errol Zeiger5, Siegfried Knasmüller6 and Nina Holland7

1 CSIRO Human Nutrition, Adelaide Australia 2 Unit of Environmental Carcinogenesis, National Cancer Research Institute Genoa, Italy 3 Laboratory for Cell Genetics, Vrije Universiteit Brussel Brussel, Belgium 4 Unit of Molecular Epidemiology, National Cancer Research Institute Genoa, Italy 5 Errol Zeiger Consulting, Chapel Hill NC, USA 6 Institute of Cancer Research, Medical University Vienna, Austria 7 School of Public Health, University of California Berkeley, CA, USA

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The buccal cell micronucleus (MN) assay, first proposed by Stich et al. (1Go,2Go), is useful as a biomarker of genetic damage caused by life-style habits (e.g. consumption of tobacco products and alcohol, micronutrient deficiency), exposures to environmental pollutants (e.g. pesticides, arsenic, formaldehyde), medical procedures (e.g. radio- and/or chemotherapy), as well as, inherited genetic defects in DNA repair (1Go–18Go).

The . . . [Full Text of this Article]

*To whom correspondence should be addressed. Email: michael.fenech@csiro.au


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