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Mutagenesis Advance Access published online on March 8, 2005
Mutagenesis, doi:10.1093/mutage/gei013
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© The Authors 2005. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please email: journals.permissions@oupjournals.org
Received November 30, 2004
Revised January 31, 2005
Accepted February 1, 2005

Original article

In vitro effect of karathane LC (dinocap) on human lymphocytes

Mustafa Çelik 1, Fatma Ünal 2*, Deniz Yüzbasioglu 2, Mehmet Ali Ergün 3, Orhan Arslan 4, and Resat Kasap 5

1 Sütçü Imam Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Kahramanmaras-Turkey
2 Gazi Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Teknikokullar, 06500 Ankara-Turkey
3 Gazi Üniversitesi, Tip Fakültesi, Tibbi Genetik Bölümü, Ankara-Turkey
4 Gazi Üniversitesi, Gazi Egitim Fakültesi, Biyoloji Egitimi Bölümü, 06500 Ankara-Turkey
5 Gazi Üniversitesi, Fen-Edebiyat Fakültesi, Istatistik Bölümü, 06500 Ankara-Turkey

* To whom correspondence should be addressed.
Fatma Ünal, E-mail: funal{at}gazi.edu.tr


  Abstract

Karathane LC (active ingredient dinocap), a contact fungicide and a non-systemic acaricide was investigated for its ability to induce chromosome aberrations (CAs) and sister chromatid exchanges (SCEs) in cultured human lymphocytes of peripheral blood. In addition to the cytogenetic analysis, the effect of karathane LC on the cell proliferation kinetics (CPK) by the replication index (RI) was studied. The mitotic index (MI) was also determined to detect the cytotoxic effect. Lymphocytes were treated with four different concentrations (5, 10, 15 and 20 µg/ml) of karathane LC for 24 and 48 h. Significant differences between exposed and non-exposed groups found in CAs, SCEs and MI demonstrate the mutagenic, clastogenic and also the cytotoxic effect of karathane LC.


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