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Mutagenesis Advance Access published online on January 24, 2006
Mutagenesis, doi:10.1093/mutage/gel001
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© The Author 2006. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received December 5, 2005
Revised January 2, 2006
Accepted January 3, 2006

Article

Cadmium-induced genotoxicity, cytotoxicity and lipid peroxidation in Allium sativum and Vicia faba

Serpil Ünyayar 1, Ayla Çelik 1 *, F. Özlem Çekiç 1, and Aysin Gözel 1

1 Department of Biology, Faculty of Science and Art, Mersin University, 33342 Mersin, Turkey

* To whom correspondence should be addressed.
Ayla Çelik, E-mail: a.celik{at}mersin.edu.tr


  Abstract

Cadmium (Cd) is one of the most toxic environmental pollutants affecting cytogenetically the various organisms. The cytogenetic damage in root tip cells exposed to cadmium nitrate (CdNO3) solutions at four different concentrations (1, 10, 100 and 200 µM) was evaluated with biological tests based on micronucleus (MN) assay in two plant species, Allium sativum and Vicia faba. Additionally to the cytogenetic analysis, lipid peroxidation analyses were performed in both A.sativum and V.faba roots. Cd enhanced the MN frequency in both A.sativum and V.faba root tip cells, but no dose-dependent. Induction of MN is not depending on CdNO3 concentrations. Besides, high concentrations of Cd decreased the mitotic index and caused the delay in mitosis stages in both plants, mainly in V.faba. On the other hand, lipid peroxidation was significantly enhanced with external Cd in V.faba. The results clearly indicate that high concentrations of cadmium induce the lipid peroxidation resulting in oxidative stress that may contribute to the genotoxicity and cytotoxicity of Cd ions.


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