Skip Navigation



Mutagenesis Advance Access published online on July 26, 2006
Mutagenesis, doi:10.1093/mutage/gel030
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/4/261    most recent
gel030v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Erdei, E.
Right arrow Articles by Berwick, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Erdei, E.
Right arrow Articles by Berwick, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received December 15, 2005
Revised January 9, 2006
Accepted June 12, 2006

Original article

Reliability of mutagen sensitivity assay: an inter-laboratory comparison

Esther Erdei 1 *, Sang-Joon Lee 1, Qingyi Wei 2, Li-E. Wang 2, Yan-S. Song 3, Dana Bovbjerg 4, and Marianne Berwick 1

1 University of New Mexico, School of Medicine, Department of Internal Medicine and New Mexico Cancer Research and Treatment Center, Albuquerque, NM, USA
2 The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
3 Memorial Sloan-Kettering Cancer Center, New York, NY, USA
4 Mount Sinai School of Medicine, New York, NY, USA

* To whom correspondence should be addressed.
Esther Erdei, E-mail: EErdei{at}salud.unm.edu


  Abstract

Mutagen sensitivity is regarded as a genetic susceptibility phenotype for various cancers; it is cytogenetically based and probably involves a number of genes from different DNA repair pathways. This assay has been used in a number of laboratories in the field of epidemiology, where it has been investigated and appears to be a useful susceptibility biomarker for epidemiological studies assessing cancer risks at the population level. One concern about phenotypic assays, such as the mutagen sensitivity assay, has been that there could be wide variation in results depending on the timing of the assay (within individual variation), the individual performing the assay (within observer variation) and the laboratory where the assay has been performed (inter-laboratory variation). We conducted an inter-laboratory comparison study between the Memorial Sloan-Kettering Cancer Center and M. D. Anderson, in which we assessed all these concerns. We did not find any significant variation in any of the assays. The correlation was high for all tests. The good concordance rate between laboratories supports the continued use of the mutagen sensitivity assay by different laboratories, and demonstrates its potential to identify at-risk subgroups among normal individuals and cancer patients alike.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
X. Wu, J. Gu, and M. R. Spitz
Mutagen Sensitivity: A Genetic Predisposition Factor for Cancer
Cancer Res., April 15, 2007; 67(8): 3493 - 3495.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.